A distinct mechanism of action

How does Xiapex work?

Xiapex contains a combination of two types of collagenase that work in a complimentary manner to dissolve the types of collagen that are predominantly present in the Dupuytren’s contracture. The two distinct collagenases are isolated and purified from the bacterium Clostridium histolyticum.1

Xiapex - mode of action1

  • Xiapex uses a precise enzymatic action that dissolves collagen in the Dupuytren’s cord.
  • Two types of collagenase (AUX-I and AUX-II) act on the types of collagen (Class I and Class III) that are predominant in the Dupuytren’s cord.
  • AUX-I cleaves the terminal ends of the collagen chain, while AUX-II cleaves the interior segment of the collagen chain.
  • These two types of collagenase work in a complementary manner to disrupt the Dupuytren’s cord.


Xiapex - mode of action1


AUX-1 and AUX-2



  1. Xiapex Summary of Product Characteristics.