Questions by patients
Will it hurt?
Some transient pain will occur. You may experience some swelling or bruising of the treated hand following the procedure.1 Your doctor will tell you how to look after your skin if this happens. Your doctor will also recommend the appropriate medication if you need pain relief.
When can I start using my hand normally again?
When your finger has been straightened, your doctor will encourage you to resume normal activities but to avoid strain for a certain period.
Will I need physiotherapy after Xiapex?
You will be expected to do the daily finger exercises recommended by your doctor. Your doctor will let you know if you require any additional physiotherapy.
How does this affect my ability to drive a car or other vehicles?
Swelling and pain can impair the function of the treated hand.1 You should therefore avoid driving, riding a motorbike or operating machinery until you get the go-ahead from your doctor.
How soon after treatment can I return to work?
Your doctor will be able to advise you on when you can resume normal or strenuous activity following treatment.
Will the treatment be affected if I take other medications?
In some cases, yes. If you are taking, or have recently taken, any other medicines, such as antibiotics to treat an infection, blood-thinning agents or non-prescription medications, you should consult your doctor.
I am pregnant. Can I be treated with Xiapex?
There are no studies on pregnant women. Treatment should therefore be postponed until after pregnancy. Treatment with Xiapex can be carried out during lactation.
When is Xiapex not recommended?
If you are you allergic to the active substance in Xiapex (collagenase clostridium histolyticum) or any of the other substances, do not undergo treatment with Xiapex.
Questions by physicians
What are the most common side effects?
The most frequently reported adverse reactions during the Xiapex clinical studies were local injection site reactions such as oedema peripheral (local to the injection site), contusion (including ecchymosis), injection site haemorrhage and injection site pain. Injection site reactions were very common, occurring in the vast majority of patients, were mostly mild to moderate in severity and generally subsided within 1-2 weeks post injection. Serious adverse reactions of tendon rupture (3 cases), tendonitis (1 case), other ligament injury (1 case) and complex regional pain syndrome (1 case) related to the medicinal product were reported in the clinical development program. Tendon rupture is very uncommon; both in clinical studies and in real world use.1, 2
Why is the Xiapex training program needed?
The European Medicines Agency has required that Sobi shall ensure that all physicians who are expected to prescribe/use the product are appropriately trained in the correct administration of the product and experienced in the diagnosis and management of the disease. Sobi offers a comprehensive training program designed to ensure proficiency and to minimize the risk of tendon ruptures and ligament injuries.
- Xiapex Summary of Product Characteristics.
- Peimer CA et al. Hand 2012; 7(2):143–6.